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PrefGel™
Root Surface Conditioner/ EDTA
24%, Ph neutral
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About PrefGel™
Mechanical debridement of root surfaces inevitably results in the formation
of a smear layer that may negatively influence periodontal repair or regeneration.
PrefGel™ is a pH neutral, root surface conditioning gel (24% EDTA in carboxy
methyl cellulose gel) that promotes effective removal of the smear layer
during periodontal surgery. It is intended for topical application onto
exposed root surfaces. PrefGel offers effective, yet gentle removal of the
smear layer without damaging the surrounding tissues. 
A Companion To Emdogain®Gel Treatment
In treatment with Emdogain®Gel, eliminating the smear layer ensures that
the enamel matrix proteins are allowed to interact with and precipitate
onto a clean root surface. This vital interaction forms the foundation
for the regain of loss periodontal tissues including new cementum, new
periodontal ligament with inserting and functionally oriented collagen
fibers and new alveolar bone.
Conditioning
Versus Etching
Etching at low pHEtching with agents operating at low pH, such as citric
acid or phosphoric acid, have been shown to remove the smear layer even
after a relatively short application time. However, etching with acids
can interfere with the periodontal healing, since there is a risk of a
possible necrotizing effect of surrounding vital periodontal tissues.
Also, it is known that low pH agents denature the collagenous matrix.
Conditioning at Neutral pHConditioning with PrefGel removes the smear
layer and exposes the collagenous matrix of dentin and cementum by selective
removal of mineral. It has also been shown that conditioning with PrefGel ™
does not interfere with the vitality of the surrounding periodontium,
which is imperative for successful periodontal healing.
Directions
For Use
Each package of PrefGel contains 10 sterilized, single-use
pipettes.
1. The pipette is opened by twisting the wing. 2. Press out the contents
into a sterile dappen dish and apply
the
gel using a minigauze, a small sterile instrument (e.g. a plastic instrument)
or a sterile syringe with a blunt
ended cannula; alternatively withdraw the contents directly from the pipette
into a syringe.
3. Remove any remaining plaque and/or calculus as well as blood from root
surfaces exposed during
periodontal
surgery.
4. Apply PrefGel™ onto exposed root surfaces for 2 minutes.
5. Rinse thoroughly with sterile saline.
6. Avoid recontamination of the conditioned root surfaces after the final
rinse and prior to treatment
with e.g. EmdogainGel.
7. After application, discard any residual gel.
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